SAMMANFATTNING Artros och skador i ledbrosk är vanliga problem hos både människor och djur, som orsakar stora fysiska besvär i form av smärta och nedsatt rörelseförmåga. Idag finns ett flertal olika behandlingsmetoder mot artros, men ännu finns ingen bra behandlingsmetod för att åstadkomma läkning av ett skadat ledbrosk. I den här studien användes kanin som modelldjur för att utvärdera en ny behandling mot artros på människa. Målet var att stimulera nybildning av ledbrosk via rekrytering av mesenkymala stamceller. Studien utfördes på 20 kaniner av rasen New Zeeland White, 6-7 månader gamla honor med en kroppsvikt på ca 4 kg. En ledskada skapades med borr på den mediala femurkondylen i kaninernas vänstra knäled under anestesi. Därefter injicerades en hyaluronsyragel enbart eller tillsammans med tillväxtfaktorn Bone morphogenic protein-2 (BMP-2) i leden.

Bakgrund: Osteoporos är en skelettsjukdom som ökar risken för frakturer. Sjukdomen i sig ärasymtomatisk men frakturerna som uppkommer leder till morbiditet och ökad mortalitet. ISverige beräknas en tredjedel av kvinnorna i åldrarna 70-79 år ha osteoporos i höften ochförekomsten förväntas öka i och med att Sverige får en allt äldre befolkning. En strategi föratt minska risken för frakturer är att öka bentätheten. På senare år har det gjorts flera studiersom undersökt om komjölksprotein kan öka bentätheten.Syfte: Att undersöka om intag av komjölksprotein påverkar benremodelleringen och/eller gerökad bentäthet hos unga människor, vilket skulle kunna leda till ett högre peak bone mass.Sökväg: Sökningar i PubMed och Scopus efter originalartiklar utfördes under april 2011.Sökord som användes var ?Milk AND bone mass/density?, ?Milk protein AND bonemass/density?, ?Milk basic protein AND bone mass/density?.Urvalskriterier: Originalartiklar på svenska/engelska som undersökt effekten av intag avmjölkprotein på bentätheten med hjälp av Dual energy X-ray absorbtiometry (DXA), samt påbenremodelleringen med hjälp av biomarkörer inkluderades.

The healing process of human bone can be aided by the presence of differentmaterials. A material that is transformed into bone when in contact with bone iscalled a boneconductive material. By transforming into bone the material reduces thetime that it takes to heal a fracture. This report is a study of existing boneconductivematerials on the market to see if there is a material available that would be suitable totest on larger fractures. The wanted application is to be able to heal fractures up to50 mm which is a fracture too big for the body to heal on its own.The healing process of human bone can be aided by the presence of differentmaterials.

Dental implants that are integrated into the jaw bones are widely used to replace lost teeth in human beings. Tooth-loss is often related to loss of the surrounding alveolar bone. This can make implant placement difficult and a bone substituting material may be required. The standard method is to use a bone graft harvested from the patient which requires additional surgery than that needed for implant placement. Limitations in the amount of bone that can be harvested also pose a problem.

Background: Many cancer patients who get bone metastases live longer thanks to the successful research and development of medicines during recent years. Many studies show general health benefits from physical activity. For patients with bone metastases the possibility of physical activity perhaps should limit? Nurses at oncological units are often in lifelong contact with this group of patients. It´s therefore important to have knowledge about the bone metastases and how it influence the patient´s possibility of performing physical activity in order to support and encourage the patient to safely physical activity.Aim: To describe the patient´s possibility of physical activity with metastases to the bone.Method: A literature study.Results: The extension of the bone metastases shall be verified through X-ray.

An inflammatory reaction is induced after release of proinflammatory mediators such asinterleukin 1 and 6 and tumour necrosis factor ?. These mediators stimulate the liver tosuppress the syntheses of albumin and endure the syntheses of acute phase protein forinstance C-reactive protein. The aim of this paper was to perform a method validation on animmune turbidimetric assay to quantify C-reactive protein in canine serum at the laboratory atSkara Animals Hospital, Skara, Sweden. The validation involved evaluation of the assaylinearity, precision, stability and recovery.The method was proved to be linear for both TruLab control and Medinor control.

The aim of this thesis is to study the possibility of the existence of a specialist in bone tools manufacturing during the Mesolithic. The thesis describes the climate during the Mesolithic, argues for an experimental approach, and describes social organization in hunter-gatherer-groups and the processes behind cultural transmission. It also gives some examples of excavation sites in Scandinavia. An experiment simulating a teaching situation is made, in addition to the theoretical information, with the intent to explore how advanced the crafting of bone really is. The physical result is then studied and documented.

Abstract:In previous experiments with the bacterium Ideonella dechloratans a probable sequencecoding for a cytochrome c protein (cyt c) was observed, the sequence is assumed to have afunction in the bacterial respiratory chain. Detection attempts have been made to try to findthis protein, but have not succeeded. The purpose of this project is to detect the expressionof mRNA associated with the cytochrome c. And if it is detected, it will also be investigated ifthere is any difference in expression of the mRNA due to aerobic or anaerobic environment.Total RNA was purified from cultures grown under aerobic and anaerobic conditions. cDNAwas then synthesized using reverse transcriptase and subsequently amplified with thespecific primers in a qRT-PCR.qRT-PCR testing showed a distinct amplification of primer product, confirming that I.dechloratans expresses mRNA coding for the cyt c protein.

Chiari type I malformation is a condition in humans characterized by a small posterior cranial fossa, downward herniation of the cerebellar tonsils, foramen magnum overcrowding and disturbances of cerebrospinal fluid dynamics. Syringohydromyelia is often seen in patients with Chiari type I malformation. Syringohydromyelia is characterized by fluid-filled cavities in the spinal cord. This causes damage to the nervous tissue in the spinal cord. In recent years, a condition similar to Chiari type I malformation has been recognized in dogs. It has mostly been seen in Cavalier King Charles spaniels (CKCS). The condition seen in dogs is usually called occipital bone hypoplasia. The aim of the study was to examine whether there is a difference in the shape of the caudal fossa between CKCS, small bred dogs with a similar head shape and dogs with a normal head shape and if occipital bone hypoplasia is related to a head shape with a steep back of the head. Other aims of the study were to examine the crowding of nervous tissue in the foramen magnum in each breed group, the extent of syringohydromyelia and to what extent the malformation had caused neurological signs. Sculls from dogs on autopsy were divided in halves and the position of the cerebellum compared to the level of the foramen magnum was studied.

This thesis is conducted together with the environmental- and health department in Halmstadcommunity. The thesis is about allowance of bedding and water supply for pig farms inHalmstad community. These farms are chosen randomly from all of the pig farms inHalmstad community. It includes inspection of 27 pig farms and writing of a report. Duringthe inspections I study the amount of bedding, what kind of bedding, water supply andinjuries like lameness, shoulder-bone sore, ear-, flank- and pig tail biting.

Kosten har stor betydelse för den idrottande individens prestation och hälsa. Trots det är det få idrottsutövare som följer kostrekommendationerna för sin idrottsgren. Styrketränande individer får ofta i sig mer protein än de behöver och under de senaste åren har användningen av proteintillskott ökat. Ett för högt intag av protein kan vara skadligt för hälsan och kostsamt för såväl plånbok som miljö. Tidigare forskning har visat ett samband mellan attityder och beteenden, vilket innebär att det är av intresse att undersöka individers attityder om man vill förändra deras beteende.

Syftet med den här litteraturstudien var att undersöka effekten av hög protein- och fettrik kost på styrketräning. De flesta dagliga matvaror innehåller oftast både protein och fett förutom rena kolhydratkällor, vilka har olika effekt på kroppen vid styrketräning. Styrketräning kan påverka proteinsyntesen, muskelhypertrofi, lipolys och fettoxidationen i kroppen. Dessa processer influeras av mängden protein eller fett som konsumeras, vilken typ av protein eller fett som konsumeras samt tidpunkten intaget sker i relation till styrketräning.Studier har visat att ett högt proteinintag i kombination med styrketräning kan leda till ökad muskelmassa och viktnedgång på grund av en ökad proteinsyntes, lipolys och fettoxidation. Tidigare forskning visar också att ett ökat fettintag stimulerar lipolys och fettoxidationen hos individer.

Cyanobacteria belong to the oldest organisms of our planet. They use photosynthesis to produce ATP and gain biomass from carbon dioxide. The cyanobacteria Nostoc punctiforme is a filamentous bacterium that consists of two different types of cells, vegetative cells and heterocysts. The type of cell it differentiates into depends on the media they grow in. In an ammonium-rich medium, the N.punctiforme consists of vegetative cells that differentiate into heterocysts when in the medium is changed to a low-concentration ammonium medium.

Background: Bone anchored hearing system is a surgically implantable system for treatment ofindividuals with hearing loss. The Softband is intended for patients who can benefit from a boneanchored hearing system but who are not yet suitable for implant surgery.Objective: The aim of this study was to investigate whether an adhesive bone conductor, Adjoin, canbe used as an alternative to Softband.Material and Method: Twenty adult subjects with normal hearing participated in the study.Measurement of functional gain and speech intelligibility was performed with Softband and Adjoinwhich then were compared. A questionnaire was answered by the participants after the measurementsthat treated their subjective experiences with each option.Results: The objective measurements yielded no overall difference between Softband and Adjoin forthe group studied. The subjective results showed differences in the perceived comfort as well as whichof the two bone conductors that would be preferred to use in everyday life, with Adjoin being thepreferred option. No difference was detected on participants perceived gain, sound quality and speechintelligibility.Conclusion: Based on the measured results, Adjoin seems to be a suitable alternative to Softband.However, there are questions about how Adjoin works with long-term use..

Som SPA-terapeuter kommer vi att arbeta mycket med huden och få mycket frågor på hur man tar hand om sin hud på bästa sätt. Därför vill vi studera samband mellan hud och näringsämnen i kosten för att se om kosten kan påverka hudtillståndet. Vår fråga är därför påverkas huden av fett, kolhydrater och protein i kosten?Vi undersöker tre av våra största näringsämnen vilka är kolhydrater, protein och fett genom att titta på vetenskapliga artiklar som har gjorts inom området..